파골세포 분화에 따른 이차원 전기영동 분석
Tow-dimensional electrophoretic analysis in osteoclast differentiation
정파진, 이홍찬, 이장희,
소속 상세정보
정파진 ( ) - 조선대학교 치과대학 미생물학
이홍찬 ( ) - 조선대학교 치과대학 미생물학
이장희 ( ) - 조선대학교 치과대학 미생물학
KMID : 0353320020260010161
Abstract
Osteoclasts, cells primarily involved in osteoporosis, are originated from the hematopoietic precursor cells of the monocyte/macrophage lineage. Proteins involved in osteoclast differentiation could be targets for drug development of osteoporosis therapy. To characterize protein expression pattern during osteoclastogenesis, we have carried out two-dimensional electrophoreses using cellular extracts from RAW 264.7 cells and mouse bone-marrow cells before and after differentiation into osteoclast-like cells. Several protein spots were found changed during differentiation. These data can serve protein expression maps for osteoclastogenesis and provide information for further analyses with MALDI-TOF for identification of the regulated proteins.
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